TÉLÉCHARGER 3310 MADD

TÉLÉCHARGER 3310 MADD

TÉLÉCHARGER 3310 MADD

T3 is O, S, or Se; each of R13a and R13b is, independently, H, optionally substituted acyl, optionally substituted alkyl, or optionally substituted alkoxy, wherein the combination of R13b and R14 can be taken together to form optionally substituted heterocyclyl; R14' is, independently, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted alkheterocyclyl, optionally substituted alkaryl, optionally substituted aminoalkyl, optionally substituted alkoxy, optionally substituted alkoxycarbonylalkyl, optionally substituted alkoxycarbonylalkoxy, optionally substituted carboxyalkoxy, optionally substituted carboxyalkyl, or optionally substituted carbamoylalkyl; and each R15 is, independently, H, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl. The isolated polynucleotide of any one of claims , further comprising a targeting moiety, wherein said targeting moiety is covalently bound to said polynucleotide. The isolated polynucleotide of claim 36, wherein said targeting moiety is an antibody, thyrotropin, melanotropin, lectin, glycoprotein, surfactant protein A, Mucin carbohydrate, multivalent lactose, multivalent galactose, N-acetyl- galactosamine, N- acetyl-gulucosamine multivalent mannose, multivalent fucose, glycosylated polyaminoacids, multivalent galactose, transferrin, bisphosphonate, polyglutamate, polyaspartate, a lipid, cholesterol, a steroid, bile acid, folate, vitamin B12, biotin, an RGD peptide, an RGD peptide mimetic, or an aptamer. A pharmaceutical composition comprising the isolated polynucleotide of any one

Nom: 3310 madd
Format:Fichier D’archive
Version:Dernière
Licence:Usage personnel seulement (acheter plus tard!)
Système d’exploitation: iOS. Windows XP/7/10. MacOS. Android.
Taille:65.41 MB

The method of claim 54, wherein the increased level of the polypeptide of interest is detectable in a bodily fluid of said patient. The method of claim 55, wherein the bodily fluid is selected from the group consisting of peripheral blood, serum, plasma, ascites, urine, cerebrospinal fluid CSF , sputum, saliva, bone marrow, synovial fluid, aqueous humor, amniotic fluid, cerumen, breast milk, broncheoalveolar lavage fluid, semen, prostatic fluid, cowper's fluid or pre- ejaculatory fluid, sweat, fecal matter, hair, tears, cyst fluid, pleural and peritoneal fluid, pericardial fluid, lymph, chyme, chyle, bile, interstitial fluid, menses, pus, sebum, vomit, vaginal secretions, mucosal secretion, stool water, pancreatic juice, lavage fluids from sinus cavities, bronchopulmonary aspirates, blastocyl cavity fluid, and umbilical cord The method of claim 56, wherein the bodily fluid is serum and the polpeptide per unit drug PUD is greater than 1.

The method of claim 57, wherein the dose splitting factor DSF is greater than 4. The method of claim 55, wherein administration is transdermal.

The method of claim 59, wherein transdermal administration comprises utilization of one or more members selected from the group consisting of a patch, cream, ointment, mechanical device, needle, sponge, depot and fabric. The method of claim 59, wherein administration is according to a dosing regimen which occurs over the course of hours, days, weeks, months, or years. The method of claim 52, wherein said two or more split doses comprise a first dose of the polynucleotide or pharmaceutical composition administered at a time T1 followed by a second dose of the polynucleotide or pharmaceutical composition administered at a time T2, wherein said time T1 and said time T2 are separated by no more than 1 minute and wherein said first dose and said second dose are administered in amounts that result in higher levels of the polypeptide of interest in said subject than if the amounts of polynucleotide or pharmaceutical composition were administered together in a single unit dose.

The method of claim 63, wherein administration occurs by direct injection. The method of claim 64, wherein direct injection is selected from the group consisting of intravenous, intradermal, subcutaneous, intramuscular and intravitreal. The method of claim 64, wherein said first dose is administered proximal to said second or plurality of doses.

The method of claim 64, wherein said first dose is administered distal to said second or plurality of doses. The method of claim 64, wherein the distance between the site of injection of said first dose and the site of injection of any second or plurality of doses is from about 1mm The method of claim 64, wherein injection is made at a depth of from 0.

The method of claim 65, wherein direct injection is achieved by using one or more devices selected from multineedle injection systems, catheter or lumen systems, and ultrasound, electrical or radiation based systems.

Madd 2019 Black 2019

The method of claim 63, wherein the amount polynucleotide or pharmaceutical composition administered in any dose is substantially equal. MADD ne réussit pourtant pas à obtenir la collaboration du gouvernement fédéral.

Especially at Christmas, MADD reminds us with a red ribbon campaign of the tragic consequences of drinking and driving.

C'est à l'époque de Noël que MADD fait le plus pour nous rappeler les tragiques conséquences que peut avoir la conduite en état d'ébriété. MADD says that current practices are making a mockery of the Canadian judicial system.

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MADD affirme que les pratiques actuelles tournent en ridicule le système judiciaire canadien. Par exemple, une part importante des revenus de l'association Les mères contre l'alcool au volant, ou MADD , provient de la sollicitation téléphonique.

Je tiens à répéter que le conseil national de MADD Canada, nos sections locales et nos membres appuient de tout coeur le projet de loi C MADD Canada hopes the red ribbon will also serve as a reminder to call and take action in ensuring our roads are safe.

MADD Canada espère que le ruban rouge servira en même temps à rappeler aux gens qu'il faut toujours aviser le service et prendre des mesures pour faire en sorte que nos routes soient sûres. I and my party concurs with MADD's position on this. À l'instar de mon parti, je souscris à la position de MADD là-dessus.

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